09:10

Doribax - Pharmacokinetics

Distribution

On average, about 8.1% of plasma proteins attached to Doripenem, it is also separate from drug concentrations of plasma. Doripenem’s distribution volume is close to that of extracellular fluid volume in humans (18.2 L). When Doripenem is essentially stable the average volume of distribution is approximately 16.8 L. Within the few of the body’s fluids and tissues, Doripenem is able to be filtered successfully as well as reach concentration levels that are able to restrain from more vulnerable bacteria than what is required.



Metabolism

When metabolized, Doripenem breaks down by means of an enzyme called dehydropeptidase-I into an inactive ring-opened metabolite.

Excretion

In young and healthy adults, the elimination half-life of Doripenem considering the average plasma terminal is normally around 1 hour. The plasma clearance is about 15.9L/hour and the average renal clearance is 10.3 L/hour. Research has been found that Doripenem is filtered by the glomerulus capillary bed in the Bowman’s capsule and the tubular secretions in the nephron.

08:36

Birth Control Options - What kind of birth?

The type of birth control you choose depends on your needs. Some people only need to prevent pregnancy. Other people may also want to protect themselves or their partners from diseases that can be passed by having sex. These diseases are called sexually transmitted infections (STIs). Some STIs include acquired immunodeficiency syndrome (AIDS), chlamydia, human papillomavirus (HPV),herpes, genital warts and syphilis.



Talk with your family doctor about the pros and cons of each birth control option


08:35

Birth Control Options - What are barrier methods?

Barrier methods include the diaphragm, the cervical cap, contraceptive sponges and condoms. These methods prevent pregnancy by blocking sperm from getting into the uterus. Barrier methods must be used every time you have sex.


diaphragm - cervical cap

A woman must visit her doctor to be fitted for a diaphragm or a cervical cap.

Using a diaphragm, cervical cap or contraceptive sponge may increase the risk of urinary tract infections in some women. Some women have allergic reactions with these methods.

08:34

Birth Control Options - Are condoms a good choice?

Yes. Condoms aren’t expensive and are widely available. Condoms are an especially good choice if you or your partner are also having sex with other people or if either of you has had sex with other people in the past.



Condoms offer the most protection against STIs of all the barrier method options. Using a spermicide with condoms can offer better protection against pregnancy, but it does not increase your protection against STIs . Spermicides containing nonoxynol-9 can cause genital irritation and can actually increase your risk of catching an STI.

Female condoms aren’t as effective as male condoms, but they may be a good choice if a man won’t use a male condom.

08:33

Birth Control Options - What about the pill?

Birth control pills work mostly by preventing ovulation (the release of an egg by the ovaries). Most pills are made of two hormones called estrogen and progestin. For the pill to work, you have to take it every day.



Some common side effects of birth control pills are nausea, headaches, acne, increased blood pressure, breast tenderness, bloating, weight gain and depression. However, not every woman who takes the pill will have side effects. You may have to try several types of birth control pills before you find the type that is best for you. The pill may reduce cramping and shorten the number of days of bleeding during the menstrual period. The pill may also help premenstrual syndrome (PMS). Women who take the pill should not smoke.

08:32

Birth Control Options - What is the vaginal contraceptive ring?

The vaginal contraceptive ring (brand name: NuvaRing) is a thin, flexible ring that is inserted into the vagina. It releases hormones that keep you from getting pregnant. These hormones are the same ones used in most birth control pills. The ring is left in the vagina for 3 weeks. It doesn’t have to be in a specific position in the vagina. You remove the ring after 3 weeks and your period will start. After 7 days, you insert a new ring.



If the ring is out of your vagina for more than 3 hours, it may not work effectively when you put it back in. To protect against pregnancy, you will need to use another form of birth control until the ring has been in all the time for 7 days in a row.

Women who use the vaginal ring should not smoke.

08:30

What about hormone shots and implants?

Hormone shots (brand names: Depo-Provera, Lunelle) work much like the pill to prevent pregnancy. They may have some side effects, such as headaches and changes in your period, mood and weight. A Depo-Provera shot prevents pregnancy for 3 months. A Lunelle shot prevents pregnancy for 1 month.



Hormone implants (brand name: Norplant System) are no longer available. If you are currently using hormone implants, you should talk to your doctor to see what your birth control options will be when your hormone implants expire. The implants prevent pregnancy for 5 years, but you can have them removed at any time.